Preclinical Medicine Books
If you have an ailment or illness and want to identify it quickly while at home, this is the guide for you.
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It has an easy-to-follow, visual symptom checker that will help you recognise the symptoms of what might be wrong and what you should do.
The head-to-toe visual diagnostic guides will also help you recognise situations that are urgent or potentially life-threatening.
In the past several years, there has been an explosion in the ability of biologists, molecular biologists and biochemists to collect vast amounts of data on their systems. Biothermodynamics, Part C presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. The use of thermodynamics in biological research is used as an "energy book-keeping system." While the structure and function of a molecule is important, it is equally important to know what drives the energy force. These methods look to answer: What are the sources of energy that drive the function? Which of the pathways are of biological significance? As the base of macromolecular structures continues to expand through powerful techniques of molecular biology, such as X-ray crystal data and spectroscopy methods, the importance of tested and reliable methods for answering these questions will continue to expand as well.
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Energy balance can be maintained by adapting energy intake to changes in energy expenditure and vice versa, where short-term changes in energy expenditure are mainly caused by physical activity. Questions are whether physical activity is affected by over and under-eating, is intake affected by an increase or a decrease in physical activity, and does overweight affect physical activity? Presented evidence is largely based on studies where physical activity is quantified with doubly labeled water. Overeating does not affect physical activity while under-eating decreases habitual or voluntary physical activity. Thus, it is easier to gain weight than to lose weight. An exercise induced increase in energy requirement is compensated by intake while a change to a more sedentary routine does not induce an equivalent reduction of intake and generally results in weight gain. Overweight and obese subjects have similar activity energy expenditures than lean people despite they move less. There are two options to reverse the general population trend for an increasing body weight, reducing intake or increasing physical activity. Based on the results presented, eating less is most effective for preventing weight gain, despite a potential negative effect on physical activity when reaching a negative energy balance.
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Research in Clinical Practice is a neat, pocket-sized reference guide examining how to get the most from actively participating in research. Including how to begin, avoiding pitfalls, whom to approach and what questions to ask - all significant practicalities for conducting research in the reader's area of interest. Each reader will learn how to make the best use of such a valuable time. Written by two experienced surgeons, both of whom achieved post graduate research degrees, Research in Clinical Practice, is an essential tool for clinicians embarking on a research project as well as those who are new to supervising researchers.
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French biologist and chemist Louis Pasteur (1822-1895) transformed medicine-and the lives of people around the world-when he developed the first rabies vaccine in 1885. Two years later, he founded the Institut Pasteur to fight infectious diseases-tuberculosis, hepatitis, tetanus, plague, influenza, and many more. For 130 years, this international organization has been at the forefront of revolutionary discoveries that have contributed enormously to major advances in medicine, in particular the isolation of HIV in 1983. With 33research units in Paris, 33 Institutes throughout the world, and 10 Nobel Prizes, the Institute has truly changed the world. This detailed, illustrated, and fully documented book sheds light on the activities and battles the Institute has led throughout its history, and its plans for the future.
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What if everything you think you know about getting older and staying healthy is . . . wrong? In The Telomere Miracle, Dr. Ed Park explores the revolutionary idea that disease and aging in humans all arises from one single source: genetic errors caused by shortening of telomeres, or the sequences of DNA at the ends of our chromosomes. Telomeres naturally shorten over time, and ultimately, as a result, our whole body deteriorates, leading to a range of ailments-including many we associate with aging, from diabetes to hypertension to macular degeneration to cancer. But as Dr. Park explains, instead of a thousand different diseases, we're really confronting one disease with a thousand faces. And we have the ability to slow down the process-or even turn it around and effectively turn back the clock. In these pages, Dr. Park conveys cutting-edge science in a lively style, using illustrations and metaphors ranging from auto parts to superheroes that everyone can relate to. Then he shows you how you can intervene in the aging process through practices and techniques that boost the activity of the enzyme telomerase-the body's internal fountain of youth on a cellular level. "The simple yet profound message you'll find here," Dr. Park writes, "is that inside your cells, your body already has the necessary tools to repair itself and to stay young forever."
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The Epstein-Barr virus (EBV) was discovered in 1964. At the time, the very idea of a virus underlying a cancer was revolutionary. Cancer is, after all, not catching. Even now, the idea of a virus causing cancer surprises many people. But Epstein-Barr, named after its discoverers, Sir Anthony Epstein and Dr Yvonne Barr, is fascinating for other reasons too. Almost everyone carries it, yet it is only under certain circumstances that it produces disease. It has been associated with different, apparently unrelated, diseases in different populations: Burkitt's Lymphoma, producing tumours in the jaw, in African children; a nasal tumour in China; glandular fever in Europe and the USA; and the majority of cases of Hodgkin's Disease everywhere. This book tells the story of the discovery of the virus, and the recognition of its connection with these various diseases - an account that spans the world and involves some remarkable characters and individual stories.
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Take charge of your health by understanding the connection between our evolutionary past and our future wellbeing with this practical guide to personalized health and nutrition-from distinguished physician Dr. Sharad Paul. Recognized as one of the best in his field, surgeon, academic, and philanthropist, Dr. Sharad Paul combines everyday health with evolutionary biology and explains how to improve your overall wellness by following a diet and exercise plan according to your gene type. Starting with our brains, this book covers everything from skin and muscles, to hearts, diets, and stress management. Throughout, Dr. Paul shares key information and provides steps to improve our daily wellbeing-impacting everything from our energy levels to memory retention to our overall longevity. Our evolutionary past and genetic makeup determine how and why the body works the way it does and how it all combines to make us unique individuals. Presenting a compelling blend of medical mysteries, patient stories, and science, Dr. Paul has developed a revolutionary approach to wellness that will result in beautiful skin at any age, a healthier diet for muscle endurance and skeletal strength, a more resilient and efficient heart, better mood and memory balance, and more.
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Everyone is a patient sooner or later. Almost everyone has some experience of being misunderstood by doctors; encounters with difficult doctors; of relationships burdened with mutual bafflement, hostility and pain. Every doctor is haunted by memories of difficult relationships with patients, of the decisions made, and the outcomes that followed. People whom, despite all of their patience, persistence, the best communication, diagnostic and reasoning skills, they haven't helped. People for whose unique suffering it seems medicine has nothing to offer. Dr. Peter Dorward explores the many ethical dilemmas that GPs must face every day, to explain why it is that despite vast resources, time, skill and dedication, medicine is so often destined to fail. His recollections include his worst failures and biggest challenges, ranging from the everyday, the tragic, the grotesque, the villainous and the humorous. The Human Kind presents a fresh understanding of the difficult relationship between doctor and patient, and the challenges which both must face.
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"A rewarding read for anyone who wants to know the unvarnished truth about how science really gets done." - Financial Times American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system--before it's too late.
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The author of Gutbliss and one of today's preeminent gastroenterologists distils the latest research on the microbiome into a practical program for boosting overall health. The microbiome - the collective name for the trillions of bacteria that live in our gut - is today's hottest medical topic. Synthesising the latest findings, Dr Robynne Chutkan explains how the standard Western diet and lifestyle are starving our microbiome, depleting the 'good bugs' that keep us healthy, and encouraging overgrowth of exactly the wrong type of bacteria. The resulting imbalance makes us more prone to disease and obesity, and negatively affects our cravings, our immunity, and even our genes. But beyond the science, what sets The Microbiome Solution apart is Dr Chutkan's powerful plan for optimising your wellbeing. Discover how our hyper-hygienic lifestyle, enforced with hand-sanitising gels and antibiotics, is stripping our bodies of their natural protective systems; learn about essential prebiotics and probiotics; read a private introduction to the stool transplant, the radical super-fix for a severe microbial imbalance; and cook for thousands of billions with recipes that replenish your microbiome. This book will bring welcome relief to the many millions worldwide who need to grow a good 'gut garden' - and enjoy healthier, happier lives.
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The scandals of poor care and repeated cover-ups in the NHS in recent years have raised serious questions about the mistreatment of NHS whistleblowers. This book is autobiographical and offers the first detailed account of the ruin of a highly competent senior doctor who blew the whistle. Dr David Drew was a NHS consultant at Walsall Manor Hospital for over 19 years, including 7 spent as head of the paediatric department, before ongoing concerns over the state of poor care led him to become a whistleblower. This put him on a collision course with senior NHS hospital managers. Removed as head of department, he was suspended on trumped up charges, faced allegations of mental illness and disciplinary action and was dismissed for Gross Misconduct and Insubordination. David's eye-opening account gives a unique insight into the NHS procedures that are used to dispose of senior management's critics - at the cost of patient care.
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American taxpayers spend $30 billion annually funding biomedical research. By some estimates, half of the results from these studies can't be replicated elsewhere-the science is simply wrong. Often, research institutes and academia emphasize publishing results over getting the right answers, incentivizing poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence. How are those with breast cancer helped when the cell on which 900 papers are based turns out not to be a breast cancer cell at all? How effective could a new treatment for ALS be when it failed to cure even the mice it was initially tested on? In Rigor Mortis, award-winning science journalist Richard F. Harris reveals these urgent issues with vivid anecdotes, personal stories, and interviews with the nation's top biomedical researchers. We need to fix our dysfunctional biomedical system-now.
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To be a medical novice who makes decisions which - if you get them wrong - might forever alter, or end, a person's life? To toughen up the hard way, through repeated exposure to life-and-death situations, clinging on until your skills, expertise and the thickness of your skin are finally a match for them? Now frame these questions in the context of a health service so overstretched and understaffed that its doctors and nurses feel every day as though they are scrabbling against the odds just to keep their patients safe. In this heartfelt, deeply personal account of life as a junior doctor in today's health service, former television journalist turned doctor, Rachel Clarke, captures the extraordinary realities of ordinary life on the NHS front line. From the historic junior doctor strikes of 2016 to the 'humanitarian crisis' declared by the Red Cross, the overstretched health service is on the precipice, calling for junior doctors to draw on extraordinary reserves of what compelled them into medicine in the first place - and the value the NHS can least afford to lose - kindness.Your Life In My Hands is at once a powerful polemic on the systematic degradation of Britain's most vital public institution, and a love letter of optimism and hope to that same health service and those who support it. This extraordinary memoir offers a glimpse into a life spent between the operating room and the bedside, the mortuary and the doctors' mess, telling powerful truths about today's NHS frontline, and capturing with tenderness and humanity the highs and lows of a new doctor's first steps onto the wards in the context of a health service at breaking point - and what it means to be entrusted with carrying another's life in your hands.
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From cosmetic surgery to euthanasia, Daniel Sokol offers a unique insight into the world of medical ethics. Drawing on his experience as a leading medical ethicist and barrister, and years of front-line experience in hospitals, Daniel sheds a light on the ethical complexities of modern medicine and guides us towards a better understanding of morality. When is it acceptable to restrain patients? Should doctors always tell patients the truth? When should life-sustaining treatment be stopped? What makes life worth living? Whichever end of the stethoscope you stand, Daniel's book will change the way you think about medicine.
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A clarion call to save humanity's most essential fellow creatures - and our health Far beneath our skin exists an unfathomable, ancient universe - an internal ecosystem that is critical to our health. Dr Martin Blaser invites us into the wilds of the human 'microbiome', unfurling its inner workings and evolution. For thousands of years, bacteria and human cells have co-existed in a relationship that has ensured the health and equilibrium of our body. But now, much like the natural world outside of us, our internal environment is being irrevocably destroyed. The culprit: some of our most revered medical advances - antibiotics - which appear to be linked to the epidemics of asthma, eczema, obesity, certain forms of cancer, and other diseases plaguing modern society. In a book that stands as the Silent Spring of its day, Blaser sounds a provocative alarm that we ignore at our peril.
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"You are not simply the sum output of your genome," write Deepak Chopra and Rudy Tanzi, Director of the Genetics and Aging Research Unit at Massachusetts General Hospital. "You are the user and inventor of your genome." For years it was accepted knowledge that genes were fixed components of our bodies, and that we as individuals were incapable of altering our genetic make-up. Yet groundbreaking research suggests that changes in lifestyle and diet can greatly influence our genetic predispositions to disease and certain physical and psychological behaviours. Moreover, the adoption of ancient Vedic practices such as yoga and meditation can create genetic mutations that allow us to lead longer and healthier lives. Super Genes includes meditation and breathing practical exercises, as well as information on how to manage risk factors for disease. Combining scientific research with insights from ancient traditions, Chopra and Tanzi show how we need not be at the mercy of our genetic inheritance. Instead, they argue, we have the power to rewire our super genes for health and happiness.
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This short memoir mixes science with human interest. It charts the author's journey working at the forefront of In Vitro Fertilisation (IVF), test tube baby research. It recounts the challenges that went into establishing IVF in the wake of Steptoe and Edwards and provides a cautionary tale of how necessary it is to pay attention to what's going on in your own family. There are no other published books that detail the development of IVF in the UK from the perspective of someone who was at the cutting edge, but it is told from a very human and personal view point to appeal to a wide variety of readers. The author started as a homeless teenager from Grimsby and later became one of the founding fathers of IVF. Throughout the 1980s and 90s and for years after that, he played a key part in its scientific progress. The dedication to bring children into the lives of thousands of infertile families, came at a cost of losing his own family.
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The topic of stem cells has been very high profile in the media in recent years. There is much public interest in stem cells but also much confusion and misinformation, with some companies already offering 'stem cell products' and bogus 'stem cell therapies'. In this Very Short Introduction, Jonathan Slack introduces stem cells; what they are, what scientists do with them, what stem cell therapies are available today, and how they might be used in future. Despite important advances, clinical applications of stem cells are still in their infancy. Most real stem cell therapy today is some form of bone marrow transplantation. Slack introduces stem cells by explaining the difference between embryonic stem cells, which exist only in laboratory cultures, and tissue-specific stem cells, which exist in our bodies. Embryonic stem cells can become any cell type in the body, so diseases that may in future be treated by functional cells derived from these sorts of stem cell include diabetes, Parkinson's disease, heart disease, and spinal trauma. He then goes on to discuss the properties of tissue-specific stem cells and the important technique of bone marrow transplantation. Slack concludes by analysing how medical innovation has occurred in this area in the past, and draws out some of the lessons for the development of new therapies in the future.
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The issue of medical ethics, from thorny moral questions such as euthanasia and the morality of killing to political questions such as the fair distribution of health care resources, is rarely out of today's media. This area of ethics covers a wide range of issues, from mental health to reproductive medicine, as well as including management issues such as resource allocation, and has proven to hold enduring interest for the general public as well as the medical practitioner. This Very Short Introduction provides an invaluable tool with which to think about the ethical values that lie at the heart of medicine. This new edition explores the ethical reasoning we can use to approach medical ethics, introducing the most important 'tools' of ethical reasoning, and discussing how argument, thought experiments, and intuition can be combined in the consideration of medical ethics. Considering its practical application, Tony Hope and Michael Dunn explore how medical ethics supports health professionals through the growing use of ethics expertise in clinical settings. They also contemplate the increasingly important place of medical ethics in the wider social context, particularly in this age of globalization, not only in healthcare practice, but also policy, discussions in the media, pressure group and activism settings, and in legal judgments. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
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'Bad Science' hilariously exposed the tricks that quacks and journalists use to distort science, becoming a 400,000 copy bestseller. Now Ben Goldacre puts the $600bn global pharmaceutical industry under the microscope. What he reveals is a fascinating, terrifying mess. Doctors and patients need good scientific evidence to make informed decisions. But instead, companies run bad trials on their own drugs, which distort and exaggerate the benefits by design. When these trials produce unflattering results, the data is simply buried. All of this is perfectly legal. In fact, even government regulators withhold vitally important data from the people who need it most. Doctors and patient groups have stood by too, and failed to protect us. Instead, they take money and favours, in a world so fractured that medics and nurses are now educated by the drugs industry. Patients are harmed in huge numbers. Ben Goldacre is Britain's finest writer on the science behind medicine, and 'Bad Pharma' is a clear and witty attack, showing exactly how the science has been distorted, how our systems have been broken, and how easy it would be to fix them.
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In Incurable Me, a maverick physician brings transparency to some of medicine's most closely guarded secrets. As he establishes a link between commerce and medical research, K. P. Stoller also explains how to treat some of the most worrisome diseases and conditions afflicting humans today--including Lyme disease, brain trauma, dementia, and autism. Dr. Stoller maintains that the best evidence in medical research is not incorporated into clinical practice unless the medical cartel has the potential to make large amounts of money promoting the results of the research. Stoller takes his provocative argument a step further, maintaining that if specific research conflicts with a powerful entity's financial interests, the likely result will be an effort to suppress or distort the results. Stoller cites numerous examples, including corporate influence on GMO labeling and public health. Stoller also explores how "revolving-door-employment" between the Centers for Disease Control and large pharmaceutical companies can affect research results--as well as our health. Written in an accessible style that is thoroughly appropriate for a lay audience, Incurable Me is a must-read for anyone interested in the state of modern medicine.
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THE SUNDAY TIMES NO.1 BESTSELLER Henry Marsh has spent four decades operating on the human brain. In this searing and provocative memoir following his retirement from the NHS, he reflects on the experiences that have shaped his career and life, gaining a deeper understanding of what matters to us all in the end.
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Antibiotics are powerful drugs that can prevent and treat infections, but they are becoming less effective as a result of drug resistance. Resistance develops because the bacteria that antibiotics target can evolve ways to defend themselves against these drugs. When antibiotics fail, there is very little else to prevent an infection from spreading. Unnecessary use of antibiotics in both humans and animals accelerates the evolution of drug-resistant bacteria, with potentially catastrophic personal and global consequences. Our best defenses against infectious disease could cease to work, surgical procedures would become deadly, and we might return to a world where even small cuts are life-threatening. The problem of drug resistance already kills over one million people across the world every year and has huge economic costs. Without action, this problem will become significantly worse. Following from their work on the Review on Antimicrobial Resistance, William Hall, Anthony McDonnell, and Jim O'Neill outline the major systematic failures that have led to this growing crisis. They also provide a set of solutions to tackle these global issues that governments, industry, and public health specialists can adopt. In addition to personal behavioral modifications, such as better handwashing regimens, Superbugs argues for mounting an offense against this threat through agricultural policy changes, an industrial research stimulus, and other broad-scale economic and social incentives.
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